Synthesis, characterization and anticancer studies of some morpholine derived Schiff bases and their metal complexes
نویسندگان
چکیده
Article history: Received on: 21/06/2014 Revised on: 13/07/2014 Accepted on: 02/08/2014 Available online: 30/10/2014 This paper reported series of complexes and their modes of coordination. The series consist of N,N’,O-donor Schiff base formed by condensation reaction of 2-hydroxyacetophenone with 4-(2-aminoethyl)morpholine. The ligand and complexes were characterized by elemental analysis, FT-IR, NMR and UV/Visible spectroscopy. The complexes showed moderate cytotoxicity mediated on MCF-7 breast cancer cell line and were selective to some extent when compared to the WRL68 normal liver cell line.
منابع مشابه
Synthesis and characterization of some transition metal complexes with new mixed-donor schiff base ligands derived from 2-hydroxynaphthaldehyde
2-[3-(2-Formylnaphthoxy)-2-hydroxypropoxy] naphthaldehyde (1) have been prepared by reaction of 2-hydroxynaphthaldehyde with 1,3-dichloro-2-propanol. New N2O3 macro-acyclic ligands (L1, L2) synthesized from the reaction of (1) with aniline or cyclohexylamine. Ni (II), Co (II) and Cu (II) complexes was prepared from reaction of Schiff-bases with metal chloride and nitrate salts. All of these com...
متن کاملSynthesis and characterization of some transition metal complexes with new mixed-donor schiff base ligands derived from 2-hydroxynaphthaldehyde
2-[3-(2-Formylnaphthoxy)-2-hydroxypropoxy] naphthaldehyde (1) have been prepared by reaction of 2-hydroxynaphthaldehyde with 1,3-dichloro-2-propanol. New N2O3 macro-acyclic ligands (L1, L2) synthesized from the reaction of (1) with aniline or cyclohexylamine. Ni (II), Co (II) and Cu (II) complexes was prepared from reaction of Schiff-bases with metal chloride and nitrate salts. All of these com...
متن کاملSynthesis and characterization of some transition metal complexes of Schiff base derived from 2,4 - dihydroxybenzaldehyde
Abstract New N2O2 type Schiff base has been designed and synthesized by condensing 2,4 dihydroxy benzaldehyde and α-naphthylamine in ethanol. Solid metal complexes of the schiff base with Cu(II), Ni(II) and Zn(II) metal ion were synthesized and characterized by elemental analysis, magnetic susceptibility, molar conductance, IR, UV-Vis and ‘H NMR spectral studies. The data shows that the c...
متن کاملSynthesis and Characterization of New Schiff Bases of Ethylenediamine and Benzaldehyde Derivatives, Along with Their Iron Complexes
Two new symmetrical Schiff bases have been prepared by the condensation of ethylenediamine and two benzaldehyde derivatives, 2-hydroxybenzaldehyde and 2,4-dimethoxybenzaldehyde. The electronic transitions within these Schiff bases molecules in chloroform solvent have been investigated by UV-Vis spectroscopy. The 1H NMR and IR spectra were studied and assigned to related groups. Furthermore,...
متن کاملNew Tetraaza Schiff Base Ligands and Their Complexes: Synthesis, Characterization and Thermodynamic Studies
Some new symmetrical tetraaza Schiff base ligands containing 2-quinolinecarboxaldehyde moiety formed from condensation reaction of 2-quinolinecarboxaldehyde and o-phenylenediamine derivatives, such as N, Nˊ-bis(2-quinolylmethylidene)-4-methoxy-1, 2-phenylenediimine (L1), N, Nˊ-bis(2-quinolylmethylidene)-4-methy-1, 2-phenylenediimine (L2), N, Nˊ-bis(2-quinolylmethylidene)-4-chloro-1, 2-phenylene...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2014